Elizabeth DeMio is well-known as a collaborative pianist, recitalist, and soloist in the Cleveland area. In addition to appearing in over 100 concerts annually with local aspiring musicians, she performs frequently with soloists such as David Requiro, John Mack, John Clouser, Michel Strauss, Umberto Clerici, Massimo La Rosa, and the Cavani Quartet, and has toured and given master classes throughout the United States, Korea, and Mexico.

As a soloist, DeMio performs often with the Trinity Cathedral Chamber Orchestra, a group in Cleveland that follows the tradition of daytime concerts in the great cathedrals of London. With that ensemble, she has performed twenty Mozart concerti and the five Beethoven concerti as well as works by Schumann, Mendelssohn, Ravel, and others. She has also appeared as soloist with the Orquesta Sinfonica de Veracruz and the Orquesta de la UNAM in Mexico. DeMio has recorded for both the Crystal and Azica labels, most recently the works of Samuel Adler and Bernard Garfield.  She currently serves on the faculty of the Cleveland Institute of Music in the collaborative piano department.